A previous study by us has demonstrated no beneficial clinical effect on the vital signs and catecholamine levels following laryngoscopy and oral endotracheal intubation, when normal saline or 1.5mg/Kg iv lidocaine was administered prior to rapid sequence induction of general anesthesia. The present study used a dose of 3.0mg/kg i.v lidocaine to determine whether a beneficial clinical effect might ensue.
@ES The results were follows:
@EN 1) The mean heart rate increased to ca. 30% at 1,3, and 5 minutes for both groups
2) The mean arterial pressures increased maximally to 19%and 7% at 1 minute in both groups
3) The mean epinephrine level increased 36% at 1 minute then decreased rapidly in the saline group, whereas the lidocaine group showed decreases of 43, 52, 50, 67 and 75% at 1, 2, 3, 5 and 10minutes, respectively.
4) The mean norepinephrine levels increased to 65, 81, 70, 72 and 60% at 1, 2, 3, 5 and 10 minutes, in the saline group, where as the increases were 71, 66, 71, 53 and 22% for the lidocaine group.
Since these findings are similar to those from our previous study, We believe there to be little justification for the use of i.v lidocaine at this dose.
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